Best approach for cleaning list?

Hi There!

I want to clean my list, but I don’t know which one is the best approach.

First, I have created a segment of the people that didn’t open any of my e-mails in the last 6 months, in which I put the tag “limbo”.

Then, I created another segment with the same structure, but now within the last 45 days (with the same tag). For this segment, I created a flow to send two emails. If the person doesn’t open, I want to put a “Limbo” tag on her. If she opens any of them, I want her to remain active.

I don’t want to “suppress” these profiles, because I want to try some re-engagement in the future.

So, what is the best way to segment these “inactive” profiles?
Should I just exclude the “people that didn’t open any email in the last 45 days” from my campaigns? If she opens any one of the two emails, Will she be removed from that list?

Should I create a flow and if she doesn't open anything, I create a “property” Limbo? This will be a problem if the same person goes in this flow 2 times? (Like, creating the property twice?)

I appreciate it if anyone could give me some tips about this!

Thank you, very much