Hey @mrvijay002, for such cases we’d generally recommend you can remove the profile from this list vs. suppressing from this list. This API endpoint will allow you to remove a profile from a list without modifying their consent status. 

An alternative approach, which we don’t generally recommend, could enable you to perform a list suppression via our unsubscribe API. You’d need to toggle off this account-level setting  (Settings > Consent Pages), then call the unsubscribe API with the related list ID; this will perform an unsubscribe only from this list but not a global unsubscribe (I.e. a list suppression). Note - this setting is only configurable for paid accounts.