Hi @Frediiicom,
I would certainly ensure when sending that you are sending to active and engaged customers. For initial big emails, it is often good to send to a larger scale database, ie; All.
However that being said and back to your point, yes absolutely. List cleaning is good practice and great to get into a habit of. There are automated ways you can do this with the Sunset Flow (See this article; https://help.klaviyo.com/hc/en-us/articles/360017518492) and it is also good to create a Win Back flow too, which tries to reengage customers who may have been away from your brand for some time.
Kylie